Artificial liver

New success in the way for creating artificial liver

Scientists from Massachusetts Institute of Technology (MIT) took a serious step to successful  creation of an artificial liver. The scientists revealed tens chemical compounds, which help cells of a liver to function and grow normally in laboratory. It means that million people having serious diseases of a liver will receive the chance to get a new artificial liver and to recover. The engineer of MIT Sangeeta Bhatia developed a way of temporary maintenance of normal work of cells of a liver for experiment in laboratory. It gave to scientists time for research of cages and studying of how they react to more than 12 thousand chemical compounds. After check of thousands cells of the liver from eight different donors’ scientists defined 12 connections which accelerate cell fission and help an artificial liver to function normally. Two of found connections especially well proved on a liver from young donors. Therefore scientists decided to test these connections on the cells of the liver, which have been grown up from induced pluripotent stem cells (iPSC). Usually it wasn’t possible to grow up hepatocytes from iPSC, because these cages didn’t reach a full maturity. And here at influence of two found chemical compounds of a cage ripened completely. Scientists intend to build in these cages a cellular framework of fabric, to replace fabric to mice and to look, whether will be able to replace these cages a liver. Besides, scientists want to learn, whether can restore the found substances a sore liver directly in an organism, that is, whether it is possible to use them as medicine. If experiments take place successfully, in treatment of the liver there will be a revolution which people with chronic diseases of this body so long ago wait.